暥晹壢妛徣丂巹棫戝妛愴棯揑尋媶婎斦宍惉巟墖帠嬈

僩僢僾儁乕僕 > 尋媶嬈愌

尨挊榑暥

2022擭

Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discov. 2022; 8: 502

Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, Miyazawa K Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells. Int J Oncol. 2022 May; 60(5): 54.

Suzuki S, Ogawa M, Miyazaki M, Ota K, Kazama H, Hirota A, Takano N, Hiramoto M, Miyazawa K. Lysosome?targeted drug combination induces multiple organelle dysfunctions and non?canonical death in pancreatic cancer cells. Oncol Rep. 2022 Feb;47(2):40.

2021擭

Saimi M, Moriya S, Li ZL, Miyaso H, Nagahori K, Kawata S, Omotehara T, Ogawa Y, Hino H, Miyazawa K, Sakabe K, Itoh M. Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells. Tokai J Exp Clin Med. 2021 Apr 20;46(1):7-16.

Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, Hino H, Kazama H, Miyazawa K. Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Int J Mol Med. 2021 Oct;48(4):195

Hattori K, Takano N, Kazama H, Moriya S, Miyake K, Hiramoto M, Tsukahara K, Miyazawa K. Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells. Oncol Lett. 2021 Sep;22(3):680

Toriyama K, Takano N, Kokuba H, Kazama H, Moriya S, Hiramoto M, Abe S, Miyazawa K. Azithromycin enhances the cytotoxicity of DNA-damaging drugs via lysosomal membrane permeabilization in lung cancer cells. Cancer Sci. 2021 Aug;112(8):3324-3337.

Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, Fujita K, Barroga E, Hiramoto M, Handa H, Kuroda M, Ishikawa T, Miyazawa K. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci Rep. 2021 Apr 22;11(1):8735.

2020擭

Hino H, Iriyama N, Kokuba H, Kazama H, Moriya S, Takano N, Hiramoto M, Aizawa S, Miyazawa K. Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes Cancer Sci. 2020 Jun;111(6):2132-2145.

Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, Hiramoto M, Tsukahara K, Miyazawa K. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin Biochem Biophys Rep. 2020 Mar 17;22:100750

Miyazawa S, Moriya S, Kokuba H, Hino H, Takano N, Miyazawa K. Vitamin K?2?induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines Breast Cancer. 2020 Mar;27(2):225-235

Teraoka S, Muguruma M,Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T. Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines J Surg Res. 2020 Jun;250:200-208.

Yokota A, Hiramoto M, Hino H, Tokuhisa M, Miyazaki M, Kazama H, Takano N, Miyazawa K. Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2 Biochem Biophys Res Commun. 2020 Aug 12:S0006-291X(20)31446-7.

2019擭

Tsugawa Y丆Hiramoto M, Imai T Estrogen induces estrogen receptor 兛 expressionand hepatocyte proliferation in late pregnancy. Biochemical and Biophysical Research Communications 511(3):592-596, 2019

Ota K丆Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M,?Miyazawa K. Fingolimod sensitizes EGFR wild?type non?small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncol Reports 42(1):231-242, 2019

Miyazawa S丆Moriya S, Kokuba H, Hino H, Takaano N, Miyazawa K Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines. Breast Cancer PMID: 31625014, Epub 2019 Oct 17

2018擭

Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K丂 Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system.丂 Biochem Biophys Res Commun. 2018 Jun 18;501(1):286-292

Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Int J Oncol. 52(4):1165-1177, 2018

Hiramoto M, Udagawa H, Ishibashi N, Takahashi E, Kaburagi Y, Miyazawa K, Funahashi N, Nammo T, Yasuda K.丂 A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression. Int J Mol Med. 41乮2乯丂717-728丆2018

Mori T, Ito T, Liu S, Ando H, Sakamoto S, Yamaguchi Y, Tokunaga E, Shibata N, Handa H, Hakoshima T. Structural basis of thalidomide enantiomer binding to cereblon. Sci. Rep. 8, 1294, 2018. doi:10.1038/s41598-018-19202-7

Fujita H, Aratani S, Yagishita N, Nishioka K, Nakajima T. Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract. Mol Med Rep.18(6):5701-5708, 2018

Maeda T, Fujita Y, Tanabe-Fujimura C, Zou K, Liu J, Liu S, Kikuchi K, Shen X, Nakajima T, Komano H. An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein. Biol Pharm Bull. 41(6):915-919,2018

Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H, Nakajima T. The NRF2-PGC-1兝 pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model. Molecular Medicine Reports. 2018

Orii N, Mizoguchi I, Chiba Y, Hasegawa H, Ohashi M, Xu M, Nagai T, Ochiai M, Mochizuki Y, Owaki T, and Yoshimoto T. Protective effects against tumors and infection by IL-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors. Oncoimmunology 2018 Jan 15;7(5)

Chiba Y, Mizoguchi I, Hasegawa H, Ohashi M, Orii N, Nagai T, Sugahara M, Miyamoto Y, Xu M, Owaki T, and Yoshimoto T. Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases. Cell Mol Life Sci. 2018 Apr;75(8):1363-1376.

Chiba Y, Mizoguchi I, Furusawa J, Hasegawa H, Ohashi M, Xu M, Owaki T, Yoshimoto T. Interleukin-27 exerts its antitumor effects by promoting differentiation of hematopoietic stem cells to M1 macrophages. Cancer Res. 2018 Jan 1;78(1):182-194.

2017擭

Wada E, Tanihata J, Iwamura A, Takeda S, Hayashi YK, Matsuda R. Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice. Skelet Muscle. 7(1):23, 2017

Nakamori M, Hamanaka K, Thomas JD, Wang ET, Hayashi YK, Takahashi MP, Swanson MS, Nishino I, Mochizuki H. Aberrant myokine signaling in congenital myotonic dystrophy. Cell Rep. 21(5):1240-1252, 2017

Kawahara G, Maeda H, Kikura-Hanajiri R, Yoshida K, Hayashi YK. The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae. Forensic Toxicol. 35:369-375, 2017

Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N. Biallelic mutations in MYPN, encoding myopalladin, are associated with childhood-onset, slowly progressive nemaline myopathy. Am J Hum Genet. 100(1):169-178, 2017

Iriyama N, Hino H, Moriya S, Hiramoto M, Hatta Y, Takei M, Miyazawa K. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells. Leukemia&Lymphoma 18:1-12. 2017

S Miyatake, et al. Biallelic mutations in MYPN, encoding myopalladin, are associated with childhood-onset, slowly progressive nemaline myopathy. Am J Hum Genet 100:169-178, 2017

2016擭

Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C-C., Miller, K., Fang, W., Wang, N-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A. and Chamberlain, P. P. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature, 535, 252-257, 2016

Nguyen, T. V., Lee, J. E., Sweredoski, M. J., Yang, S. J., Jeon, S. J., Harrison, J. S., Yim, J. H., Lee, S. G.,丂Handa, H., Kuhlman, B., Jeong, J. S., Reitsma, J. M., Park, C. S., Hess, S. and Deshaies, R. J. Glutamine triggers acetylation-dependent degradation of glutamine丂synthetase via the thalidomide receptor cereblon. Mol. Cell, 61, 809-820, 2016

Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M. M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B. Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem.Biol., 11, 1245?1254, 2016

Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi,Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat. Commun., 7, 11030, 2016

Aratani S, Fujita H, Kuroiwa Y, Usui C, Yokota S, Nakamura I, Nishioka K, Nakajima T, 乬Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.乭Sci.Rep. 6; 36943, 2016

Yukio S, Mabuchi Y, Miyamoto K, Araki D, Niibe K, Houlihan DD, Morikawa S, Nakagawa T, Nakajima T, Akazawa C, Hori S, Okano H, Matsuzaki Y, 乬Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression.乭 PLOS ONE 11(11):e0165946, 2016

Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T, 乬Inhibitory effects of ubiquitination of synoviolin by PADI4.乭 Mol. Med. Rep. in press ,2016

Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T, 乬Mitochondrial ubiquitin ligase activator of NF-內B regulates NF-內B signaling in cells subjected to ER stress.乭 Int J Mol Med. 37: 1611-8, 2016

Maeda T, Tanabe-Fujimura C, Fujita Y, Abe C, Nanakida Y, Kun Zou, Liu J, Liu S, Nakajima T, Komano H. 乬NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-inducible endoplasmic reticulum protein.乭 Biochem Biophys Res Commun. 473(4): 1276-1280, 2016

G Kawahara, YK Hayashi. Characterization of zebrafish models of Marinesco-Sjogren syndrome. PLoS One 11:e0165563,2016

M Furuta, et al. An elderly-onset limb girdle muscular dystrophy type 1B (LGMD1B) with pseudo-hypertrophy of paraspinal muscles. Neuromuscul Disord 26:593-597,2016

Hasegawa, H., Mizoguchi, I., Chiba, Y., Ohashi, M., Xu, M. and Yoshimoto, T. Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family. Front. Immunol ;7:479,2016

Kimura, Y., Nagai, N., Tsunekawa, N., Sato-Matsushita, M., Yoshimoto, T., Cua, D., Iwakura, Y., Yagita, H., Okada, F., Tahara, H., Saiki, I., Irimura, T. and Hayakawa, Y. IL-17A-producing CD30+ V兟1 T cells drive inflammation-induced cancer progression. Cancer Sci. 107(9):1206-14,2016

Furusawa, J., Mizoguchi, I., Chiba, Y., Hisada, M., Kobayashi, F., Yoshida, H., Nakae, S., Tsuchida, A., Matsumoto, T., Ema, H., Mizuguchi, J., and Yoshimoto, T. Promotion of expansion and differentiation of hematopoietic stem cells by interleukin-27 into myeloid progenitors to control infection in emergency myelopoiesis. PLoS Pathog. 12(3), 2016

Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K, Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K. Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines. Int J Oncol. 2016 Nov;49(5):1848-1858. 2016

Mukai S1, Moriya S2, Hiramoto M2, Kazama H2, Kokuba H3, Che XF2, Yokoyama T4, Sakamoto S5, Sugawara A6, Sunazuka T6, ?mura S6, Handa H7, Itoi T1, Miyazawa K2. Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. International Journal of Oncology 48(1):45-54, 2016

Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu M, Hiramoto M, Tsukahara K, Miyazawa K. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. PlosOne 11(12):e0164529, 2016

Klionsky DJ, Abdelmohsen K, Abe A,et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.s ,2016

2015擭

Ito, T. and Handa, H.丂Another action of a thalidomide derivative丏(News and Views) Nature, 523, 167-168, 2015

Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Magnus J.H, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Eskil E, Nishioka K, Nakajima T., 乬The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1兝. 乭 EMBO J. 34: 425-577, 2015

Nakajima F, Aratani S, Fujita H, Yagishita N, Ichinose S, Makita K, Setoguchi Y, Nakajima T, 乬Synoviolin inhibitor LS102 reduces endoplasmic reticulum stress-induced collagen synthesis in an in vitro model of stress-related interstitial pneumonia. 乭 Int J Mol Med. 35: 110-116, 2015

M Yuen, et al. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. J Clin Invest 125:456-457,2015

A Uruha,et al. Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure. J Neurol, Neurosurg, Psych 86:483-489,2015

C Matsuda, et al. Dysferlinopathy fibroblasts are defective in plasma membrane repair. PLoS Currents 7,2015

Y Endo, et al. Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca(2)(+) channels. Hum Mol Genet 24:637-648,2015

Y Endo, et al. Milder forms of muscular dystrophy associated with POMGNT2 mutations, Neurol Genet 1:e33,2015

M Dong, et al. DAG1 mutations associated with asymptomatic hyperCKemia and hypoglycosylation of alpha-dystroglycan. Neurology 84:273-279,2015

Yoshimoto, T., Chiba, Y., Furusawa, J., Xu, M., Tsunoda, R., Higuchi, K., and Mizoguchi, I. Potential clinical application of interleukin-27 as an antitumor agent. Cancer Sci., 106 (9), 1103-1110, 2015

Mizoguchi, I., Chiba, Y., Furusawa, J., Xu, M., Tsunoda, R., Higuchi, K., and Yoshimoto, T. Therapeutic potential of interleukin-27 against cancers in preclinical mouse models. Oncoimmunology, 2015 May 27;4(10):e1042200. DOI:10.1080/2162402X.2015.1042200

Hiramoto M, Udagawa H, Watanabe A, Miyazawa K, Ishibashi N, Kawaguchi M, Uebanso T, Nishimura W, Nammo T, Yasuda K. Comparative analysis of type 2 diabetes-associated SNP alleles identifies allele-specific DNA-binding proteins for the KCNQ1 locus.International Journal of Molecular Medicine. ;36(1):222-30.2015

Sugita S, Ito K, Yamashiro Y, Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K. EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. Biochem Biophys Res Commun. 461(1):28-34 2015

Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress mediated cell death in multiple myeloma cells. International Journal of Oncology. 46: 474-486, 2015

Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress?mediated cell death in multiple myeloma cells. Int J Oncol. 2015 Feb;46(2):474-86 2015

2014擭

Chamberlain, P. P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L. G., Ren, Y. J., Wang, M., Riley, M., Delker, S. L., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. O. and Cathers, B. E. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol., 21, 803-809, 2014.

Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H. and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., 5, 4263, 2014

Sakamoto, S., Omagari, K., Kita, Y., Mochizuki, Y., Naito, Y., Kawata, S., Matsuda, S., Itano, O., Jinno, H., Takeuchi, H., Yamaguchi, Y., Kitagawa, Y. and Handa, H. Magnetically Promoted Rapid Immunoreactions Using Functionalized Fluorescent Magnetic Beads: A Proof of Principle. Clinical Chem., 60, 610-620, 2014

Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thankurta, A., Klippel, A., Handa, H., Daniel, T. O., Schafer, P. H. and Chopra, R. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN. Br. J. Haematol., 164, 811-821, 2014

Terada, K., Tanaka, T., Hanyu, N., Honda, T. and Handa, H. Rapid and sensitive detection of alpha-fetoprotein by a magnetically promoted shake-free immunoassay employing fluorescent magnetic nanobeads. Int. J. Anal. Bio-Sci., 2, 101-107. 2014

T Yonekawa,et al. Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice. Brain 137:2670-2679,2014

S Miyatake, et al. Deep sequencing detects very-low-grade somatic mosaicism in the unaffected mother of siblings with nemaline myopathy. Neuromuscul Disord 24:642-647,2014

S Kajino, et al. Congenital fiber type disproportion myopathy caused by LMNA mutations, J Neurol Sci 340:94-98,2014

M Goto,et al. A nationwide survey on Marinesco-Sjogren syndrome in Japan. Orphanet J Rare Diseases 9:58,2014

T Fujii, et al. A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles. J Neurol Sci 343:206-210,2014

RP Anada, et al. Absence of beta-amyloid deposition in the central nervous system of a transgenic mouse model of distal myopathy with rimmed vacuoles, Amyloid 21:138-139,2014

妛夛丒島墘夛

敿揷丂岹 乽Cereblon Modulators乿 Kyushu Hematology Forum丂2017.2.18.丂僌儔儞僪僴僀傾僢僩暉壀

敿揷丂岹丄庬巗戝婌丄嶳杮弤堦丄挬嵢抦巕丄嵅摗抭旤丄埨摗廏庽丄埳摗戱悈 乽傾僼傿僯僥傿帴惈價乕僘偵傛傞昗揑場巕偺摨掕偐傜憂栻傑偱乿 巹棫戝妛愴棯揑尋媶婎斦宍惉帠嬈乽婡擻惈帴惈僫僲價乕僘媄弍傪婎斦偲偡傞擄帯惈幘姵偵偍偗傞僞儞僷僋幙暘夝婡峔偺夝柧偲怴婯帯椕朄偺奐敪乿拞娫曬崘丂2017.1.30.丂搶嫗堛壢戝妛

埳摗戱悈丄嵅摗抭旤丄埨摗廏庽丄挬嵢抦巕丄嶳杮弤堦丄庬巗戝婌丄敿揷丂岹 乽CRBN偺惗暔妛揑堄媊偺夝愅乿巹棫戝妛愴棯揑尋媶婎斦宍惉帠嬈乽婡擻惈帴惈僫僲價乕僘媄弍傪婎斦偲偡傞擄帯惈幘姵偵偍偗傞僞儞僷僋幙暘夝婡峔偺夝柧偲怴婯帯椕朄偺奐敪乿 拞娫曬崘丂丂2017.1.30.丂搶嫗堛壢戝妛

敿揷丂岹 乽傾僼傿僯僥傿帴惈價乕僘偺奐敪偐傜憂栻傊偺揥奐 -僒儕僪儅僀僪嵜婏惈偺僞亅僎僢僩摨掕偐傜峈偑傫嵻奐敪-乿 愭恑僶僀僆僼僅乕儔儉2017丂2017.1.28丂戝嶃晎棫戝妛丂

媨尨偐撧 丄 怷扟徃懢丄暯郪堦峗丄暯杮丂惓庽丄彫徏惤堦榊丄愇愳丂岶丄媨郪孾夘 乽Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER-stress loading in breast cancer cell lines乿丂 戞177夞 搶嫗堛壢戝妛堛妛夛憤夛丄 2016擭6寧4擔丄搶嫗堛壢戝妛昦堾丄(搶嫗)

暯郪堦峗 丄 捤尨惔彶丄怷扟徃懢丄暯杮惓庽丄晽娫岹旤丄桼揷弤丄垻晹峎媣丄媨郪孾夘丄媨尨偐撧丄堫捗惓恖丂 乽Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells. 乿丂 戞177夞 搶嫗堛壢戝妛堛妛夛憤夛丄 2016擭6寧4擔丄搶嫗堛壢戝妛昦堾丄(搶嫗)

媨郪孾夘乮嫵堢島墘乯 乽儅僋儘儔僀僪偲僆乕僩僼傽僕乕乿丂 戞23夞儅僋儘儔僀僪怴嶌梡尋媶夛. 2016.7.30.丂(搶嫗)

暯杮惓庽 丄 怷扟徃懢丄晲懞弤丄晽娫岹旤丄擔栰峗巏丄崅栰捈帯丄垻晹峎媣丄媨郪孾夘丂 乽岝斀墳惈僋儘僗儕儞僇乕偲帴惈僫僲價乕僘傪梡偄偨暘巕昗揑扵嶕偺帋傒乿 戞89夞丂擔杮惗壔妛夛戝夛丂2016擭9寧乮愬戜乯

暯郪堦峗 丄 捤尨惔彶丄怷扟徃懢丄暯杮惓庽丄媨郪孾夘丄媨尨偐撧 乽傾儈僲巁婹夓忬懺壓偱丄儅僋儘儔僀僪宯峈嬠栻偼僆乕僩僼傽僕乕慾奞偵傛傝摢栩晹娻嵶朎姅偺嵶朎巰傪桿摫偡傞乿 戞75夞擔杮娻妛夛妛弍廤夛 2016擭10寧乮墶昹乯

媨尨偐撧 丄 怷扟徃懢丄暯郪堦峗丄暯杮惓庽丄彫徏惤堦榊丄愇愳丂岶丄垻晹峎媣丄媨郪孾夘 丂 乽價僲儗儖價儞偼擕娻嵶朎姅偵墬偄偰傾僌儕僜乕儉宍惉傪慾奞偡傞偙偲偵傛傝儃儖僥僝儈僽桿摫惈偺嵶朎撆惈傪憹嫮偡傞乿丂 戞75夞擔杮娻妛夛妛弍廤夛 2016擭10寧乮墶昹乯

怷扟徃懢 丄 晽娫岹旤丄丂暯杮惓庽丄丂憡郪怣丄嵒捤晀柧丄敿揷丂岹丄媨郪孾夘 乽Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells乿丂 戞178夞 搶嫗堛壢戝妛堛妛夛憤夛 2016擭11寧5擔丂搶嫗堛壢戝妛昦堾丂(搶嫗)

暯郪堦峗 丄 捤尨惔彶丄怷扟徃懢丄暯杮惓庽丄晽娫岹旤丄桼揷丂弤丄垻晹峎媣丄媨郪孾夘丄媨尨偐撧丄堫捗惓恖 乽Macrolide antibiotics exhibit cytotoxic effect under amino acid-depleted culture condition via blocking autophagy flux in head and neck squamous cell carcinoma cell lines乿 戞178夞 搶嫗堛壢戝妛堛妛夛憤夛丂 2016擭11寧5擔丂搶嫗堛壢戝妛昦堾丂(搶嫗)

埳摗戱悈丄敿揷丂岹 乽媫惈崪悜惈敀寣昦偵岠壥傪帵偡怴婯偺僙儗僽儘儞儌僕儏儗乕僞乕乿 戞39夞擔杮暘巕惗暔妛夛擭夛丂2016.12.1(11.30-12.2)丂僷僔僼傿僐墶昹

Handa H. 乽Identification of a target of thalidomide using our affinity nanobead technology and development of novel drugs based on the target乿 Japan-Spain Joint Workshop on Nanomedicine Research丂2016.12.1(12.1-12.2)丂Institute of Health Carlos III (ISCIII), Madrid (Spain)

敿揷丂岹 乽Cereblon Modulators乿 ImiDs Forum 2016丂2016.11.7.丂偑傫尋媶夛桳柧

埳摗戱悈丄敿揷丂岹 乽媫惈崪悜惈敀寣昦偵桳岠側怴婯僙儗僽儘儞儌僕儏儗乕僞乕偺奐敪乿丂 戞89夞擔杮惗壔妛夛戝夛丂2016.9.25(9.25乣9.27)丂搶杒戝妛

敿揷丂岹 乽僙儗僽儘儞儌僕儏儗乕僞乕乿 Kyoto IMiDs Forum丂2016.9.24.丂嫗搒戝妛丂

Handa H. 乽Cereblon; a direct target of immunomodulatory agents乿 2016 the Japanese Society of Medical Oncology Annual Meeting (戞14夞擔杮椪彴庮釃妛夛妛弍廤夛)丂2016.7.30.(7.28-7.30丂Kobe International Exhibition Hall

Handa H. 乽Cereblon (CRBN), the common target of multiple pharmacological actions of thalidomide and its derivatives乿 UCLA CTSI Seminar Series 2016.3.23.丂 UCLA David Geffen School of Medicine

敿揷丂岹 乽僒儕僪儅僀僪昗揑場巕僙儗僽儘儞摨掕偐傜怴偨側懡敪惈崪悜庮帯椕栻偺奐敪乿 暥晹壢妛徣巹棫戝妛愴棯揑尋媶婎斦宍惉巟墖帠嬈戞堦夞恑捇忬嫷曬崘夛丂2016.1.27丂搶嫗堛壢戝妛

Nakajima T. 乽Synoviolin, as a new stellar factor for understanding chronic inflammation.乿 MOSCOW INTERNATIONAL FORUM OF BONES AND JOINTS DISORDERS/THE INTERNATIONAL SCHOOL CONFERENCE (ISC) 2016.4.18-21. Moscow

Aratani S, Nakajima T丂 乽 Synoviolin, as a novel factor for understanding obesity and metabolic disorders based on chronic inflammation.乿 International Conference on Obesity and Chronic Diseases (ICOCD-2016) 2016.7.25-27. Las Vegas

Aratani S, Fujita H, Yagishita N, Yokota M, Nishioka K, Nakajima T 乽E3 Ubiquitin ligase synoviolin inhibitors has effects on obesity. 乿丂 International Conference on Obesity and Chronic Diseases (ICOCD-2016) 2016.7.25-27 Las Vegas.

峳扟憦巕丄摗揷塸弐丄惣壀媣庻庽丄拞搰棙攷丂 乽E3 儐價僉僠儞壔峺慺僔僲價儕僆儞慾奞嵻偺椪彴墳梡傊偺壜擻惈乿 戞 177 夞搶嫗堛壢戝妛堛妛夛憤夛丂2016.6.4.丂搶嫗

峳扟憦巕丄摗揷塸弐丄敧栘壓彯巕丄拞搰庒枻丄惣壀媣庻庽丄拞搰棙攷丂 乽僔僲價僆儕儞慾奞嵻偺幚梡壔偵岦偗偰乿丂 戞 5 夞堛栻岺 3 戝妛曪妵楢実悇恑僔儞億僕僂儉丂2016.6.18.丂搶嫗

摗揷塸弐丄峳扟憦巕丄恵摗僇僣巕丄堫捗惓恖丄尨捈旤丄撪栰攷擵丄惣壀媣庻庽丄拞搰棙攷丂 乽Synoviolin is a key regulator in chronic inflammation.乿丂 戞 5 夞堛栻岺 3 戝妛曪妵楢実悇恑僔儞億僕僂儉丂2016.6.18.丂搶嫗

拞搰棙攷丂 乽怴婯帺屓墛徢徢岓孮儌僨儖儅僂僗偺庽棫偲僔僲價僆儕儞慾奞嵻偺岠壥乿丂 戞 17 夞 塣摦婍壢妛尋媶夛丂2016.9.2-3.丂戝嶃

摗揷塸弐丂 乽儕僂儅僠敪徢場巕僔僲價僆儕儞偵傛傞僄僱儖僊乕戙幱挷愡偺夝柧乿丂 戞17 夞 塣摦婍壢妛尋媶夛丂2016.9.2-3.丂戝嶃

峳扟憦巕丂 乽僔僲價僆儕儞慾奞嵻偺幚梡壔偵岦偗偰乿丂 戞 17 夞 塣摦婍壢妛尋媶夛丂2016.9.2-3丂戝嶃

摗揷塸弐丄峳扟憦巕丄惣壀媣庻庽丄拞搰棙攷丂 乽僔僲價僆儕儞慾奞嵻偺扵嶕乿丂 擔杮慄堐嬝捝徢妛夛丂戞 8 夞妛弍廤夛丂2016.9.17-18.丂搶嫗

摗揷塸弐丄峳扟憦巕丄惣壀媣庻庽丄拞搰棙攷丂 乽儅僂僗儌僨儖傪梡偄偨僔僲價僆儕儞慾奞妶惈傪桳偡傞揤慠暔偺岠壥偺専徹乿 擔杮慄堐嬝捝徢妛夛丂戞 8 夞妛弍廤夛丂2016.9.17-18.丂搶嫗

摗揷塸弐丄峳扟憦巕丄惣壀媣庻庽丄拞搰棙攷丂 乽僸僩偵偍偗傞僔僲價僆儕儞慾奞嵻偺岠壥偺専徹乿丂 擔杮慄堐嬝捝徢妛夛丂戞 8 夞妛弍廤夛丂2016.9.17-18.丂搶嫗

拞搰棙攷丂 乽僔僲價僆儕儞偑戱偔枬惈墛徢丒娭愡儕僂儅僠偺昦懺儊僇僯僘儉偲怴婯帯椕朄偺奐敪乿丂 戞 31 夞擔杮惍宍奜壢妛夛丂婎慴妛弍廤夛丂2016.10.13-14.丂暉壀

椦桼婲巕丂 乽妀枌昦儌僨儖儅僂僗偺嬝昦懺夝愅乿丂 戞89夞擔杮栻棟妛夛擭夛丂僔儞億僕僂儉23丂崪奿嬝尋媶偺怴揥奐丗幘姵帯椕丒憂栻偵岦偗偰丂2016.3.9-11. 僷僔僼傿僐墶昹

Hayashi HY, Wada E, Kawahara G 乽A new mouse model for myopathy associated with nuclear envelopathy.乿丂 戞93夞擔杮惗棟妛夛戝夛丂2016.3.22-24.丂嶥杫僐儞儀儞僔儑儞儂乕儖

Kawahara G, Hayashi HY 乽Novel zebrafish models of neuromuscular diseases.乿丂 戞93夞擔杮惗棟妛夛戝夛丂2016.3.22-24.丂嶥杫僐儞儀儞僔儑儞儂乕儖

愳尨尯棟丄椦桼婲巕丂 乽儅儕僱僗僐-僔僃乕僌儗儞徢岓孮偺僛僽儔僼傿僢僔儏儌僨儖偺夝愅乿 戞2夞擔杮嬝妛夛妛弍廤夛丂2016.8.5-6. NCNP 搶嫗

Kawahara G, Hayashi YK 乽A zebrafish model of Marinesco-Sjogren syndrome.乿 ASHG 2016 Annual Meeting 2016.10.18-22. Vancouver Canada

愳尨尯棟丄椦桼婲巕丂 乽僛僽儔僼傿僢僔儏傪梡偄偨恄宱嬝幘姵尋媶乿丂 嬝惗棟偺廤偄2016.12.17. 帨宐堛戝丂搶嫗

怷扟徃懢 丄彫徏惤堦榊丄嶳�眽棱n丄壨崌桪桟丄殸応姲巕丄幵嬇朏丄堫捗惓恖丄屻摗柧旻丄暯杮惓庽丄敿揷 岹丄媨郪孾夘 乽Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress mediated cell death in multiple myeloma cells.乿丂 堛妛夛彠椼徿丂戞175夞 搶嫗堛壢戝妛堛妛夛憤夛丄2015擭6寧6擔丂 搶嫗堛壢戝妛昦堾丂搶嫗

埳摗尓懢榊 丄悪揷隳暯丄嶳忛桪懢楴丄怷扟徃懢丄幵嬇朏丄暯杮惓庽丄墶嶳抭墰丄媨郪孾夘丂 乽EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.乿丂 戞175夞 搶嫗堛壢戝妛堛妛夛憤夛丄2015擭6寧6擔丂 搶嫗堛壢戝妛昦堾丂搶嫗

Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K 乽Targeting autophagy with clarithromycin enhances gefitinib-induced cell death in non-small cell lung cancer cells.乿丂 戞74夞擔杮娻妛夛妛弍廤夛 2015擭10寧丂柤屆壆

怷扟徃懢 丄 幵嬇朏丄墶嶳丂抭墰丄暯杮惓庽丄媨郪孾夘 丂 乽僋儔儕僗儘儅僀僔儞暪梡偵傛傞僎僼傿僠僯僽桿摫惈僆乕僩僼傽僕乕傪昗揑偲偟偨攛娻嵶朎姅偺嶦嵶朎岠壥偺憹嫮乿丂 戞74夞 擔杮娻妛夛妛弍憤夛丄2015擭10寧8-10擔 柤屆壆崙嵺夛媍応丂柤屆壆

岦堜弐懢榊 丄 怷扟徃懢丄暯杮惓庽丄晽娫岹旤丄殸応姲巕丄墶嶳抭墰丄敿揷丂岹丄巺堜棽晇丄媨郪孾夘 丂乽Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.乿 戞176夞 搶嫗堛壢戝妛堛妛夛憤夛丂 2015擭11寧7擔丂搶嫗堛壢戝妛昦堾丂搶嫗

埳摗尓懢榊 丄 悪揷丂隳暯丄嶳忛桪懢楴丄怷扟丂徃懢丄幵丂丂嬇朏丄暯杮惓庽丄墶嶳抭墰丄媨郪孾夘丂乽EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.乿丂堛妛夛彠椼徿戞176夞 搶嫗堛壢戝妛堛妛夛憤夛丂 2015擭11寧7擔丂搶嫗堛壢戝妛昦堾丂搶嫗

Handa H丂 乽Cereblon (CRBN), the common target of multiple pharmacological actions of thalidomide and its derivatives乿 New developments of zebrafish research丂2015.11.24

摗揷塸弐丄峳扟憦巕丄拞搰棙攷丄恵摗僇僣巕丄拞搰庒枻丄堫捗惓恖丄惣壀媣庻庽丄尨捈旤丄撪栰攷擵丂 乽枬惈墛徢偲旍枮偲傪偮側偖僔僲價儕僆儞偵偍傞僄僱儖僊乕戙幱挷愡婡峔乿丂 戞175夞搶嫗堛壢戝妛堛妛夛憤夛丂2015擭6寧6擔丂搶嫗

峳扟憦巕丄摗揷塸弐丄敧栘壓彯巕丄拞搰庒枻丄惣壀媣庻庽丄拞搰棙攷丂 乽巹偨偪偑奐敪偟偨悽奅弶偺 E3 儐價僉僠儞壔峺慺僔僲價僆儕儞慾奞嵻偺壜擻惈乿丂 戞5夞丂堛栻岺3戝妛曪妵楢実悇恑僔儞億僕僂儉丂2015擭6寧20擔丂搶嫗

摗揷塸弐丄峳扟憦巕丄敧栘壓彯巕丄恵摗僇僣巕 丄撪栰攷擵丄堫捗惓恖丄塒堜惓旻丄惣壀媣庻庽丄拞搰棙攷丂 乽儕僂儅僠敪徢場巕僔僲價僆儕儞偵傛傞僄僱儖僊乕戙幱挷愡婡峔乿丂 戞5夞丂堛栻岺3戝妛曪妵楢実悇恑僔儞億僕僂儉丂2015擭6寧20擔丂搶嫗

峳扟憦巕丂 乽巹払偑奐敪偟偨悽奅弶偺 E3 儐價僉僠儞壔峺慺僔僲價僆儕儞慾奞嵻 LS 僔儕乕僘偺壜擻惈偵偮偄偰乿丂 戞16夞 塣摦婍壢妛尋媶夛丂2015擭9寧12擔丂幁帣搰

峳扟憦巕丄摗揷塸弐丄惣壀媣庻庽丄拞搰棙攷丂 乽E3儐價僉僠儞壔峺慺僔僲價儕僆儞慾奞嵻偺椪彴墳梡傊偺壜擻惈乿丂 戞176夞搶嫗堛壢戝妛堛妛夛憤夛丂2015擭11寧7擔丂搶嫗

Mizoguchi I, Chiba Y, Xu M, Yoshimoto T. 乽Binding of Epstein-Barr virus-induced gene 3 to calnexin enhances its chaperone activity and augments interleukin-23 receptor expression, leading to development of colitis.乿 戞44夞擔杮柶塽妛夛憤夛丒妛弍廤夛丂2015擭11寧18-20擔丂嶥杫

怷扟徃懢 丄 幵 丂嬇朏 丄 暯杮惓庽 丄 媨郪孾夘 丄 彫徏惤堦榊 丄 嶳�眽棱n 丄 壨崌桪桟 丄 殸応姲巕 丄 堫捗惓恖 丄 屻摗柧旻 丄 敿揷 岹丂 乽Targetng aggresome formation under simultaneous inhibition of proteasome and autophagy potentiates ER-stress mediated cell death in myeloma cells.乿 戞173夞搶嫗堛壢戝妛堛妛夛憤夛丂2014.6.7丂搶嫗

怷扟徃懢 丄 彫徏惤堦榊 丄 幵丂嬇朏 丄 屻摗柧旻 丄 媨郪孾夘丂 乽Simultaneous targeting aggresome, proteasome, and autophagy potentiates ER-s tress mediated cell death in myeloma cells.乿 戞73夞擔杮娻妛夛丂2014.9.25.丂墶昹

怷扟徃懢 丄 彫徏惤堦榊 丄 嶳�眽棱n 丄 殸応姲巕 丄 淎揷埢巕 丄 幵丂丂嬇朏 丄 堫捗惓恖 丄 屻摗柧旻 丄 暯杮惓庽 丄 媨郪孾夘丂 乽Targeting aggresome formation enhances ER-stress mediated cell death in myeloma cells. 乿丂 戞76夞擔杮寣塼妛夛妛弍廤夛丂2014.10.30.戝嶃

媨郪孾夘乮摿暿島墘乯 乽憿寣婍庮釃偵偍偗傞嵶朎撪僞儞僷僋幙暘夝僱僢僩儚乕僋傪昗揑偲偡傞怴婯帯椕朄乿 榁擭幰憿寣婍幘姵尋媶夛. 2014.11.20. 搶嫗

Ito T, Ando H, Yamaguchi Y, Handa H 乽Cereblon is a substrate receptor of the Cul4 ubiquitin ligase whose substrate recognition is modulated by IMiDs乿 戞37夞擔杮暘巕惗暔妛夛擭夞丂2014.11.26.丂僷僔僼傿僐墶昹

曅嶳旤庽丄埳摗戱悈丄埨摗廏庽丄嶳岥梇婸丄敿揷丂岹 乽E3儐價僉僠儞儕僈乕僛偺婎幙擣幆儗僙僾僞乕CRBN偲億儅儕僪儅僀僪埶懚揑側婎幙Aiolos偺惗壔妛揑夝愅乿 戞37夞擔杮暘巕惗暔妛夛擭夞丂2014.11.25丂僷僔僼傿僐墶昹

敿揷丂岹 乽婡擻惈僫僲價乕僘偺堛妛丒堛椕傊偺墳梡乿暥晹壢妛徣 巹棫戝妛愴棯揑尋媶婎斦宍惉巟墖帠嬈 乽婡擻惈帴惈僫僲價乕僘媄弍傪婎斦偲偡傞擄帯惈幘姵偺僞儞僷僋幙暘夝惂屼婡峔偺夝柧偲怴婯帯椕朄偺奐敪乿 僉僢僋僆僼僔儞億僕僂儉丂2014.10.8.丂搶嫗堛壢戝妛

敿揷丂岹 乽IMiDs偺僙儗僽儘儞傪夘偟偨懡條側栻棟嶌梡乿 Sinnjuku Myeloma Conference丂2014.7.24丂崙嵺堛椕尋媶僙儞僞乕

Ito T, Ando H, Yamaguchi Y, Handa H 乽Cereblon is a substrate receptor of the CUL4-DDB1 ubiquitin ligase whose activity is directly controlled by thalidomide and its analogs乿 Protein Modification & Homeostasis丂2014.6.16-20.丂Suzhou Duxhu Lake Conference Center丂Suzhou China

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